But is HTR necessarily connected to psychedelia or just correlated? I’m not aware of anyone having tested DOI-NBOMe, but human reports of DOB-NBOMe suggest some sort of ceiling effects at the very least (which does not mean the Gi paper is correct at all).
I think a couple papers suggested that 5-HT2A-dominant antipsychotics signal through Gi at 5-HT2A-D2 heterodimers as well
Hold that thought....and then watch it fade away
I don’t follow
But is HTR necessarily connected to psychedelia or just correlated? I’m not aware of anyone having tested DOI-NBOMe, but human reports of DOB-NBOMe suggest some sort of ceiling effects at the very least (which does not mean the Gi paper is correct at all).
True dat
Bryan, As they in soccer (football) "well struck"!
I'm amazed that neither (apparently) the authors nor the reviewers are aware of a yuuuge amount of contradictory data previously published.....