Congratulations on seeing the technology reach human trials, that's a rare arc to live through.
A question your framing raises: the Cell result rescued locomotion, tremor, and motor skill in the models, which is restoration of function in circuits that are still there. Does the path to 'cure' you're imagining mean halting the underlying degeneration, or is circuit modulation more like a far more precise, programmable version of deep brain stimulation, controlling symptoms in surviving circuits?
Curious where you'd put chemogenetics on that line, since the answer probably shapes which of these trials counts as success.
Congratulations on seeing the technology reach human trials, that's a rare arc to live through.
A question your framing raises: the Cell result rescued locomotion, tremor, and motor skill in the models, which is restoration of function in circuits that are still there. Does the path to 'cure' you're imagining mean halting the underlying degeneration, or is circuit modulation more like a far more precise, programmable version of deep brain stimulation, controlling symptoms in surviving circuits?
Curious where you'd put chemogenetics on that line, since the answer probably shapes which of these trials counts as success.
Good question. We will not know until we see trial results.
Keep the hope coming. My wife's sister-in-law has Parkinsonism.