Operational model R.I.P.?
Dear Bryan:
In addition to the seminal work by Terry Kenakin on the quatification of bias agonism
https://doi.org/10.1021/cn200111m
you may consider complementary approaches such as
https://doi.org/10.1038/s41598-017-15258-z
for the application of the method to the case of agonists with different maximum responses (full and partial agonists) and
https://doi.org/10.1111/bph.14190
for the case of constitutively active receptors.
I’ll look into it and get back to you
Dear Bryan:
In addition to the seminal work by Terry Kenakin on the quatification of bias agonism
https://doi.org/10.1021/cn200111m
you may consider complementary approaches such as
https://doi.org/10.1038/s41598-017-15258-z
for the application of the method to the case of agonists with different maximum responses (full and partial agonists) and
https://doi.org/10.1111/bph.14190
for the case of constitutively active receptors.
I’ll look into it and get back to you