Binding affinity ≠ functional activity
Lisuride is an ultrapotent 5-HT1A agonist.
https://pubs.acs.org/doi/10.1021/acsptsci.3c00192
Read this paper https://www.cell.com/neuron/abstract/S0896-6273(25)00470-2
We have a large paper on the pharmacology of psychedelics. The situation is waaay more complex than you imagine
waay more indeed :)
Lisuride is an ultrapotent 5-HT1A agonist.
https://pubs.acs.org/doi/10.1021/acsptsci.3c00192
Read this paper https://www.cell.com/neuron/abstract/S0896-6273(25)00470-2
We have a large paper on the pharmacology of psychedelics. The situation is waaay more complex than you imagine
waay more indeed :)